Comprehensive Guide: Medicare Coverage for Zilretta

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Zilretta is an FDA-approved extended-release corticosteroid injection that offers long-lasting pain relief for individuals with osteoarthritis knee pain. It provides a non-opioid treatment option, delivering medication directly to the affected area to help manage pain and improve mobility. Zilretta can be a game-changer for Medicare beneficiaries struggling with knee pain, allowing them to regain control over their daily activities.

Does Medicare Cover Zilretta?

Medicare coverage for Zilretta falls under Part B and Part D, with specific guidelines and requirements. Let’s explore the coverage details for each part:

Medicare Part B Coverage

Medicare Part B covers medically necessary services and supplies, including certain injections administered in a healthcare provider’s office. While Zilretta is typically administered by a healthcare professional, it falls under Part B coverage if specific conditions are met. These conditions include:

  • The injection is deemed medically necessary by the treating healthcare professional.
  • The injection is administered in a doctor’s office or outpatient facility.
  • The injection is not self-administered by the beneficiary.
  • The beneficiary meets Medicare’s medical criteria for Zilretta usage.

If these conditions are met, Medicare Part B may cover a portion of the cost for Zilretta under the beneficiary’s outpatient benefits.

Medicare Part D Coverage

Medicare Part D provides coverage for prescription drugs, including Zilretta, when it is prescribed and obtained through a pharmacy. However, coverage under Part D is subject to the specific formulary of the beneficiary’s prescription drug plan (PDP). It is essential to review your plan’s formulary to determine if Zilretta is included and the associated cost-sharing requirements.

To obtain coverage for Zilretta under Part D, you may need to follow these steps:

  1. Check your plan’s formulary: Review your PDP’s formulary to ensure Zilretta is included and at what coverage level (e.g., generic, preferred brand, non-preferred brand).
  2. Prior authorization: Your PDP may require prior authorization from your healthcare provider to establish medical necessity for Zilretta.
  3. Step therapy: Some plans may require you to try and fail on other medications before providing coverage for Zilretta. This process, known as step therapy, aims to control costs and ensure the most appropriate treatment is pursued.
  4. Cost-sharing: Your PDP will outline the cost-sharing responsibilities, including copayments or coinsurance amounts, which may vary based on the specific tier Zilretta falls under.

Medicare Advantage Plans

Medicare Advantage plans (Part C) also cover Zilretta, but the coverage details may vary depending on the specific plan. These plans combine Part A, Part B, and often Part D benefits into a single package offered by private insurance companies. To determine the coverage for Zilretta under a Medicare Advantage plan, you should consult your plan documents or contact your plan directly.

Important Considerations for Medicare Beneficiaries

Before pursuing Zilretta treatment, there are a few essential considerations to keep in mind:

  1. Medical necessity: It is crucial to consult with your healthcare provider to determine if Zilretta is an appropriate treatment option for your specific condition and symptoms.
  2. Prior authorization and step therapy: As mentioned earlier, some plans may require prior authorization or step therapy. Ensure you are familiar with your plan’s requirements to streamline the approval process.
  3. Cost-sharing: Understand the potential out-of-pocket expenses associated with Zilretta, such as copayments, coinsurance, and deductibles. Review your plan’s summary of benefits or contact your plan for specific cost details.
  4. Network providers: If you have a Medicare Advantage plan or receive Part B coverage, verify that your healthcare provider and the facility where the injection will be administered are within your plan’s network.


  • Zilretta is an extended-release corticosteroid injection for osteoarthritis knee pain.
  • Medicare Part B may cover Zilretta when specific conditions are met, such as medical necessity and administration in a healthcare provider’s office.
  • Medicare Part D coverage for Zilretta is subject to the formulary of the beneficiary’s prescription drug plan.
  • Medicare Advantage plans also provide coverage for Zilretta, but the specifics depend on the individual plan.

For more information and resources on Medicare coverage for Zilretta, please refer to the following authoritative sources:

Remember, it is crucial to consult your healthcare provider and review your plan’s documents for personalized guidance and the most up-to-date information regarding Medicare coverage for Zilretta.

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