Medicare Coverage for Xifaxan: Comprehensive Information and Eligibility

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Xifaxan, with the generic name Rifaximin, is an antibiotic medication primarily prescribed to treat conditions such as traveler’s diarrhea and irritable bowel syndrome with diarrhea (IBS-D) in adults. It works by stopping the growth of bacteria in the intestines, thereby relieving symptoms associated with these conditions.

Medicare Part D: Prescription Drug Coverage

Medicare Part D is the segment of Medicare that provides coverage for prescription drugs. To determine whether Xifaxan is covered under your Medicare plan, you need to examine the details of your specific Part D plan. Medicare Part D plans are offered by private insurance companies approved by Medicare, and each plan has its own formulary, which is a list of covered drugs.

It is essential to review your plan’s formulary to determine if Xifaxan is included. Formularies are organized into tiers, and drugs in different tiers may have different coverage levels and associated costs. Typically, medications placed in lower tiers have lower copayments or coinsurance, while those in higher tiers may involve higher out-of-pocket costs.

Medicare Part B: Coverage for Xifaxan

Medicare Part B covers certain medications that are administered in a doctor’s office or hospital outpatient setting. However, Xifaxan is primarily an oral medication taken at home, which means it is generally not covered under Part B. Instead, coverage for Xifaxan is more commonly found under Medicare Part D, as mentioned earlier.

Medicare Advantage Plans and Xifaxan Coverage

Medicare Advantage plans (Part C) are an alternative to Original Medicare (Parts A and B) and are offered by private insurance companies. These plans provide all the benefits of Original Medicare and often include additional coverage, such as prescription drugs.

If you are enrolled in a Medicare Advantage plan, you should review the plan’s formulary to determine whether Xifaxan is covered. Similar to standalone Part D plans, Medicare Advantage plans have their own formularies, and coverage levels may vary. It’s important to note that if a Medicare Advantage plan covers Xifaxan, you must receive the medication from a network pharmacy to obtain the plan’s coverage.

Xifaxan Coverage and Medical Necessity

While determining coverage for Xifaxan, it is crucial to consider the concept of medical necessity. Medicare requires that medications be deemed medically necessary for coverage to be provided. Medical necessity means that the medication is prescribed for the treatment of a specific condition and is considered appropriate and effective.

To establish medical necessity, your healthcare provider will need to document the condition being treated and the reasons why Xifaxan is the appropriate course of treatment. This documentation is necessary for Medicare coverage, and without it, you may be responsible for the full cost of the medication.

Xifaxan Coverage: Cost-Sharing and Prior Authorization

When Xifaxan is covered by your Medicare plan, you may still be responsible for certain costs, such as copayments, coinsurance, or deductibles. These out-of-pocket expenses can vary depending on your specific plan and the coverage stage you are in (e.g., deductible, initial coverage, or the coverage gap, also known as the “donut hole”).

Additionally, some Medicare plans may require prior authorization for Xifaxan coverage. Prior authorization is a process in which your healthcare provider must obtain approval from your plan before prescribing a specific medication. Failure to obtain prior authorization, if required by your plan, may result in denial of coverage or increased out-of-pocket costs.


In conclusion, understanding Medicare coverage for Xifaxan involves considering your specific Medicare plan, reviewing formularies, assessing medical necessity, and potentially dealing with cost-sharing and prior authorization requirements. By exploring the resources mentioned above and consulting with your healthcare provider, you can make informed decisions regarding the coverage and usage of Xifaxan under your Medicare plan.


  • Medicare coverage for Xifaxan depends on your specific Medicare plan and its formulary.
  • Xifaxan is typically covered under Medicare Part D rather than Part B.
  • Medicare Advantage plans may also offer coverage for Xifaxan, subject to plan-specific formularies.
  • Medical necessity, cost-sharing, and prior authorization requirements are important factors to consider.
  • Useful resources:,, National Institute on Aging, U.S. Food and Drug Administration (FDA).

Useful Links:

  • The official U.S. government website for Medicare, where you can find official publications, forms, and comprehensive information on Medicare coverage.
  • The official U.S. government website for Medicaid, which provides health coverage to certain low-income individuals and families. It can be a useful resource for understanding the relationship between Medicare and Medicaid, especially for those who are dually eligible for both programs.
  • National Institute on Aging: An institute of the National Institutes of Health (NIH), dedicated to providing reliable information on aging-related topics. Their resources can be helpful in understanding Medicare coverage for older adults and navigating healthcare options.
  • U.S. Food and Drug Administration (FDA): The FDA’s official website offers comprehensive information about medications, including drug approvals, safety warnings, and labeling information. It can be a valuable resource for understanding the regulatory aspects of medications like Xifaxan.

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