Medicare Coverage for Xtandi: Exploring Options for Treatment

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Xtandi, also known by its generic name enzalutamide, is a prescription medication primarily used in the treatment of metastatic castration-resistant prostate cancer (mCRPC). This innovative drug works by inhibiting the growth of cancer cells and is often prescribed when other treatments have been ineffective.

Medicare Part A and B Coverage for Xtandi

When it comes to Medicare coverage for Xtandi, it’s important to consider the different parts of Medicare. Medicare Part A generally covers inpatient hospital stays, while Medicare Part B focuses on outpatient services and medications administered by healthcare professionals.

Regarding Xtandi, Medicare Part B coverage may be applicable if the drug is administered in an outpatient setting, such as a hospital or a clinic. However, it’s essential to note that coverage criteria and costs can vary based on individual circumstances, including the specific Medicare plan chosen and any supplemental coverage.

Medicare Part D Prescription Drug Plans

For individuals seeking coverage for Xtandi as an outpatient prescription drug, Medicare Part D plays a vital role. Medicare Part D plans are provided by private insurance companies approved by Medicare, and they offer coverage for a range of prescription medications.

It is important to review the formularies of various Part D plans to ensure that Xtandi is included. Some plans may require prior authorization, step therapy, or quantity limits. Additionally, Part D plans often involve cost-sharing through premiums, deductibles, coinsurance, and copayments.

Medicare Advantage Plans and Xtandi Coverage

Medicare Advantage (Part C) plans are an alternative to Original Medicare (Parts A and B). These plans, offered by private insurance companies, provide all the benefits of Original Medicare and often include additional coverage options, such as prescription drugs.

If you have a Medicare Advantage plan, it’s crucial to review its formulary and coverage rules to determine if Xtandi is included. Coverage details and costs can vary widely between different Medicare Advantage plans, so thorough research is essential to find the most suitable option for your needs.

Considerations for Coverage and Cost

When assessing Medicare coverage for Xtandi, it’s crucial to consider factors such as formularies, prior authorization requirements, cost-sharing, and any applicable coverage limitations. Consulting with a healthcare professional, such as your doctor or a Medicare specialist, can provide valuable insights tailored to your specific situation.

It’s also worth exploring potential financial assistance programs that may help mitigate the costs associated with Xtandi. Pharmaceutical manufacturers often offer patient assistance programs or copay assistance programs, which can be accessed through their websites or by contacting their customer support.

Exploring Alternative Treatment Options

While Xtandi is a widely used medication for the treatment of mCRPC, it’s important to discuss alternative treatment options with your healthcare provider. Other medications, therapies, or clinical trials may be available that could potentially complement or serve as alternatives to Xtandi. Your doctor can provide expert guidance based on your individual circumstances and medical history.


Understanding Medicare coverage for Xtandi is crucial for individuals seeking effective treatment options for metastatic castration-resistant prostate cancer. By exploring the coverage aspects of Medicare Parts A, B, and D, as well as Medicare Advantage plans, individuals can make informed decisions about their healthcare choices. It is also important to consider alternative treatment options and explore financial assistance programs to alleviate the potential financial burden associated with Xtandi.


  • Xtandi (enzalutamide) is a prescription medication used to treat metastatic castration-resistant prostate cancer (mCRPC).
  • Medicare Part B covers Xtandi if administered in an outpatient setting, while Medicare Part D covers it as an outpatient prescription drug.
  • Medicare Advantage plans may also provide coverage for Xtandi, but specific formularies and rules vary.
  • Considerations such as formularies, cost-sharing, and alternative treatment options should be explored.

Helpful Links:

  1. – Medicare Coverage of Enzalutamide
  2. National Cancer Institute – Prostate Cancer Treatment
  3. American Cancer Society – Understanding Medicare Advantage Plans

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